ABSTRACT
Despite discovering new antibiotics, mortality due to septic shock has remained high. This research has examined the effect of selenase in patients with septic shock admitted to the intensive care unit [ICU] of a hospital in Tehran. This double-blind clinical trial was done on 80 participants [40 case and 40 control] who were admitted to the ICU with septic shock. Every participant in the case group was administered 500 micro g selenase twice daily for 10 days. In contrast, each participant of the control group was treated with placebo [normal saline]. Data were collected by observation and recorded in a questionnaire. Chi-square and Student's t-test were used for data analysis. In this study 34 participants [42.5%] were men and 46 [57.5%] were women. The duration stay in the ICU in treatment group was less than in the observation group which was statistically significant [P =.01]. There was also a significant difference regarding the frequency of morbidity and mortality rates between the two groups [P =.03 and P =.02, respectively]. Selenium at a dosage of 500 micro g [twice daily] is effective in those who have suffered from septic shock. Still, more studies are needed to determine the best dosage and administration method of this drug
ABSTRACT
Increased intra-abdominal pressure [IAP] results in dysfunction of vital organs. The aim of the present study was to evaluate the effect of mechanical ventilation mode on IAP. In a cohort study, a total of 60 patients aged 20-70 years who were admitted to the ICU and underwent mechanical ventilation were recruited. Mechanical ventilation included one of the three modes: Biphasic positive airway pressure [BIPAP] group, synchronize intermittent mandatory ventilation [SIMV] group, or continuous positive airway pressure [CPAP] group. For each patient, mechanical ventilation mode and its parameters, blood pressure, SpO2, and status of tube feeding and IAP were recorded. Our findings indicate that the study groups were not significantly different in terms of anthropometric characteristics including age [64.5 +/- 4, P = 0.1], gender [male/female 31/29, P = 0.63], and body mass index [24 +/- 1.2, P = 0.11]. Increase IAP was related to the type of respiratory mode with the more increased IAP observed in SIMV mode, followed by BIPAP and CPAP modes [P = 0.01]. There were significant correlations between increased IAP and respiratory variables including respiratory rate, pressure support ventilation, and inspiratory pressure [P < 0.05]. Tube feeding tolerance through NG-tube was lower in SIMV group, followed by BIPAP and CPAP groups [P < 0.05]. There is a significant relationship between respiratory modes and IAP; therefore, it is better to utilize those types of mechanical ventilation like CPAP and BIPAP mode in patients who are prone to Intra-abdominal hypertension